Format

Send to

Choose Destination
J Clin Microbiol. 2015 Aug;53(8):2781-4. doi: 10.1128/JCM.00891-15. Epub 2015 Jun 10.

Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.

Author information

1
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing, China.
2
Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Tsinghua University, Beijing, China.
3
National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.
4
Department of Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.
5
National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China huanghairong@tb123.org bjavid@gmail.com.
6
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing, China huanghairong@tb123.org bjavid@gmail.com.

Abstract

Drug resistance to tuberculosis remains a major public health threat. Here, we report two cases of extended-spectrum extensively drug-resistant (XXDR) tuberculosis showing resistance to most first- and second-line agents. The results of a correlation of whole-genome sequencing (WGS) and phenotypic testing were discordant, suggesting that overreliance on WGS may miss clinically relevant resistance in extensively drug-resistant disease.

PMID:
26063862
PMCID:
PMC4508398
DOI:
10.1128/JCM.00891-15
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center