Format

Send to

Choose Destination
Genes Dev. 2015 Jun 1;29(11):1095-105. doi: 10.1101/gad.263863.115.

Human telomerase: biogenesis, trafficking, recruitment, and activation.

Author information

1
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado 80309, USA.
2
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado 80309, USA thomas.cech@colorado.edu.

Abstract

Telomerase is the ribonucleoprotein enzyme that catalyzes the extension of telomeric DNA in eukaryotes. Recent work has begun to reveal key aspects of the assembly of the human telomerase complex, its intracellular trafficking involving Cajal bodies, and its recruitment to telomeres. Once telomerase has been recruited to the telomere, it appears to undergo a separate activation step, which may include an increase in its repeat addition processivity. This review covers human telomerase biogenesis, trafficking, and activation, comparing key aspects with the analogous events in other species.

KEYWORDS:

biogenesis; cancer; recruitment; telomerase; telomere; trafficking

PMID:
26063571
PMCID:
PMC4470279
DOI:
10.1101/gad.263863.115
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center