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J Hematol Oncol. 2015 Jun 11;8:68. doi: 10.1186/s13045-015-0162-0.

MiRNA-based therapeutic intervention of cancer.

Author information

1
Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. Srivatsava.Naidu@cruk.manchester.ac.uk.
2
Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. Peter.Magee@cruk.manchester.ac.uk.
3
Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. michela.garofalo@cruk.manchester.ac.uk.

Abstract

MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have linked erratic expression of miRNAs to carcinogenesis and have provided solid evidence for their potential in cancer therapy. This review briefly summarises the recent knowledge on the involvement of miRNAs in tumourigenesis and reviews current studies on the therapeutic strategies and advances in the delivery of miRNAs.

PMID:
26062952
PMCID:
PMC4465004
DOI:
10.1186/s13045-015-0162-0
[Indexed for MEDLINE]
Free PMC Article

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