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Hum Reprod. 2015 Sep;30(9):2107-9. doi: 10.1093/humrep/dev128. Epub 2015 Jun 9.

Live birth after autograft of ovarian tissue cryopreserved during childhood.

Author information

1
Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Fertility Clinic, Department of Obstetrics and Gynaecology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium idemeest@ulb.ac.be.
2
Gynecology Clinic, Department of Obstetrics and Gynaecology, Erasme Hospital, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
3
Department of Hematology-Oncology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), 1020 Brussels, Belgium.
4
Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Present address: Instituto Marqués, Assisted Reproduction Service, Manuel Girona 33, MASIA, 08034 Barcelona, Spain.
5
Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Fertility Clinic, Department of Obstetrics and Gynaecology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium Present address: Nivelles Hospital, Rue Samiette, 1400 Nivelles, Belgium.
6
Department of Endocrinology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), 1020 Brussels, Belgium.
7
Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Fertility Clinic, Department of Obstetrics and Gynaecology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
8
Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Department of Endocrinology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), 1020 Brussels, Belgium.

Abstract

Ovarian insufficiency is a major long-term adverse event, following the administration of a myeloablative conditioning regimen, and occurring in >80% of children and adolescents receiving such treatment for malignant or non-malignant disease. Cryopreservation of ovarian tissue is currently offered to preserve the fertility of these young patients. At least 35 live births have been reported after transplantation of cryopreserved ovarian tissue in adult patients, but the procedure remains unproven for ovarian tissue harvested at a prepubertal or pubertal age. We report here the first live birth after autograft of cryopreserved ovarian tissue in a woman with primary ovarian failure after a myeloablative conditioning regimen as part of a hematopoietic stem cell transplantation performed for homozygous sickle-cell anemia at age 14 years. This first report of successful fertility restoration after the graft of ovarian tissue cryopreserved before menarche offers reassuring evidence for the feasibility of the procedure when performed during childhood.

KEYWORDS:

childhood; fertility preservation; live birth; ovarian tissue cryopreservation; transplantation

PMID:
26062556
DOI:
10.1093/humrep/dev128
[Indexed for MEDLINE]

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