Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2015 Jun 10;10(6):e0129443. doi: 10.1371/journal.pone.0129443. eCollection 2015.

Electronic Cigarettes Efficacy and Safety at 12 Months: Cohort Study.

Author information

1
Department of Medicine and Aging Sciences, University of Chieti, via dei Vestini 5, 66013, Chieti, Italy; Local Health Unit of Pescara, Via Renato Paolini 47, 65100, Pescara, Italy; "University G. d'Annunzio" Foundation, Via Colle dell'Ara, 66013, Chieti, Italy; Regional Healthcare Agency of Abruzzo, Via Attilio Monti 9, 65127, Pescara, Italy.
2
Department of Medicine and Aging Sciences, University of Chieti, via dei Vestini 5, 66013, Chieti, Italy; Local Health Unit of Pescara, Via Renato Paolini 47, 65100, Pescara, Italy.
3
Department "G. F. Ingrassia"- Hygiene and Public Health, University of Catania, Piazza Università 2, 95131, Catania, Italy.
4
Department of Clinical Sciences and Community Health, University of Milan, Via Vanzetti 5, 20133, Milan, Italy.
5
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Viale Regina Elena 324, 00161, Roma, Italy.
6
Department of Public Health Sciences, University of Turin, Via Santena 5/bis, Turin, 10124, Italy.
7
Department of Movement Sciences and Wellbeing, University Parthenope of Neaples, Via Medina 40, 80133, Napoli, Italy.
8
Local Health Authority of Lanciano-Vasto-Chieti, Via Martiri Lancianesi, 66100, Chieti, Italy.
9
Department of Medicine and Aging Sciences, University of Chieti, via dei Vestini 5, 66013, Chieti, Italy; "University G. d'Annunzio" Foundation, Via Colle dell'Ara, 66013, Chieti, Italy.
10
Local Health Unit of Pescara, Via Renato Paolini 47, 65100, Pescara, Italy.
11
Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Largo Francesco Vito, 1, 00168, Roma, Italy.
12
Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Largo Francesco Vito, 1, 00168, Roma, Italy; Italian Institute of Health, Viale Regina Elena 299, 00161, Rome, Italy.

Abstract

OBJECTIVE:

To evaluate the safety and efficacy as a tool of smoking cessation of electronic cigarettes (e-cigarettes), directly comparing users of e-cigarettes only, smokers of tobacco cigarettes only, and smokers of both.

DESIGN:

Prospective cohort study. Final results are expected in 2019, but given the urgency of data to support policies on electronic smoking, we report the results of the 12-month follow-up.

DATA SOURCES:

Direct contact and structured questionnaires by phone or via internet.

METHODS:

Adults (30-75 years) were included if they were smokers of ≥1 tobacco cigarette/day (tobacco smokers), users of any type of e-cigarettes, inhaling ≥50 puffs weekly (e-smokers), or smokers of both tobacco and e-cigarettes (dual smokers). Carbon monoxide levels were tested in a sample of those declaring tobacco smoking abstinence.

MAIN OUTCOME MEASURES:

Sustained smoking abstinence from tobacco smoking at 12 months, reduction in the number of tobacco cigarettes smoked daily.

DATA SYNTHESIS:

We used linear and logistic regression, with region as cluster unit.

RESULTS:

Follow-up data were available for 236 e-smokers, 491 tobacco smokers, and 232 dual smokers (overall response rate 70.8%). All e-smokers were tobacco ex-smokers. At 12 months, 61.9% of the e-smokers were still abstinent from tobacco smoking; 20.6% of the tobacco smokers and 22.0% of the dual smokers achieved tobacco abstinence. Adjusting for potential confounders, tobacco smoking abstinence or cessation remained significantly more likely among e-smokers (adjusted OR 5.19; 95% CI: 3.35-8.02), whereas adding e-cigarettes to tobacco smoking did not enhance the likelihood of quitting tobacco and did not reduce tobacco cigarette consumption. E-smokers showed a minimal but significantly higher increase in self-rated health than other smokers. Non significant differences were found in self-reported serious adverse events (eleven overall).

CONCLUSIONS:

Adding e-cigarettes to tobacco smoking did not facilitate smoking cessation or reduction. If e-cigarette safety will be confirmed, however, the use of e-cigarettes alone may facilitate quitters remaining so.

REGISTRATION NUMBER:

NCT01785537.

PMID:
26061661
PMCID:
PMC4464650
DOI:
10.1371/journal.pone.0129443
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center