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Mem Inst Oswaldo Cruz. 2015 Jun;110(4):569-72. doi: 10.1590/0074-02760150192. Epub 2015 Jun 9.

First report of autochthonous transmission of Zika virus in Brazil.

Author information

1
Laboratório de Virologia Molecular, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, PR, Brasil.
2
Secretaria Estadual de Saúde do Rio Grande do Norte, Natal, RN, Brasil.
3
Instituto de Medicina Tropical, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.

Abstract

In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.

PMID:
26061233
PMCID:
PMC4501423
DOI:
10.1590/0074-02760150192
[Indexed for MEDLINE]
Free PMC Article

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