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Eur Radiol. 2016 Mar;26(3):656-63. doi: 10.1007/s00330-015-3863-4. Epub 2015 Jun 10.

MR elastography of the liver at 3.0 T in diagnosing liver fibrosis grades; preliminary clinical experience.

Author information

1
Department of Radiology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan. kengo@fukuoka-u.ac.jp.
2
Department of Radiology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan.
3
Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan.

Abstract

OBJECTIVES:

To clarify the usefulness of 3.0-T MR elastography (MRE) in diagnosing the histological grades of liver fibrosis using preliminary clinical data.

MATERIALS AND METHODS:

Between November 2012 and March 2014, MRE was applied to all patients who underwent liver MR study at a 3.0-T clinical unit. Among them, those who had pathological evaluation of liver tissue within 3 months from MR examinations were retrospectively recruited, and the liver stiffness measured by MRE was correlated with histological results. Institutional review board approved this study, waiving informed consent.

RESULTS:

There were 70 patients who met the inclusion criteria. Liver stiffness showed significant correlation with the pathological grades of liver fibrosis (rho = 0.89, p < 0.0001, Spearman's rank correlation). Areas under the receiver operating characteristic curve were 0.93, 0.95, 0.99 and 0.95 for fibrosis score greater than or equal to F1, F2, F3 and F4, with cut-off values of 3.13, 3.85, 4.28 and 5.38 kPa, respectively. Multivariate analysis suggested that grades of necroinflammation also affected liver stiffness, but to a significantly lesser degree as compared to fibrosis.

CONCLUSIONS:

3.0-T clinical MRE was suggested to be sufficiently useful in assessing the grades of liver fibrosis.

KEY POINTS:

MR elastography may help clinicians assess patients with chronic liver diseases. Usefulness of 3.0-T MR elastography has rarely been reported. Measured liver stiffness correlated well with the histological grades of liver fibrosis. Measured liver stiffness was also affected by necroinflammation, but to a lesser degree. 3.0-T MRE could be a non-invasive alternative to liver biopsy.

KEYWORDS:

3.0 T; Chronic liver disease; Fibrosis; MR elastography; Necroinflammation

PMID:
26060066
DOI:
10.1007/s00330-015-3863-4
[Indexed for MEDLINE]

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