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Sci Rep. 2015 Jun 10;5:11252. doi: 10.1038/srep11252.

A key role for TGF-β1 in hippocampal synaptic plasticity and memory.

Author information

1
1] Department of Drug Sciences, University of Catania, Catania, Italy [2] IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
2
Department of Biomedical and Biotechnological Sciences - Section of Physiology, University of Catania, Catania, Italy.
3
Section of Pharmacology, University of Catania, Catania, Italy.

Abstract

Transforming Growth Factor β1 (TGF-β1) is a well-known neuroprotective and neurotrophic factor demonstrated to play a role in synaptic transmission. However, its involvement in physiological mechanisms underlying synaptic plasticity and memory at hippocampal level has not been thoroughly investigated. Here, we examine the role of TGF-β1 in hippocampal long-term potentiation (LTP) and memory in adult wild type mice. Our data provide evidence that administration of exogenous TGF-β1 is able to convert early-phase-LTP into late-phase-LTP. Furthermore, we show that the block of the endogenous TGF-β1 signaling pathway by the specific TGF-β1 inhibitor SB431542, impairs LTP and object recognition memory. The latter impairment was rescued by administration of exogenous TGF-β1, suggesting that endogenously produced TGF-β1 plays a role in physiological mechanisms underlying LTP and memory. Finally, TGF-β1 functional effect correlates with an increased expression of the phosphorylated transcription factor cAMP-Responsive Element Binding protein.

PMID:
26059637
PMCID:
PMC4462026
DOI:
10.1038/srep11252
[Indexed for MEDLINE]
Free PMC Article

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