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J Med Virol. 2016 Jan;88(1):1-12. doi: 10.1002/jmv.24292. Epub 2015 Jun 25.

Effects of cannabinoids and their receptors on viral infections.

Author information

1
Departmentof Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
2
Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3
Department of Immunology, Medical University of Warsaw, Center of Biostructure Research, Warsaw, Poland.

Abstract

Cannabinoids, the active ingredient in marijuana, and their derivatives have received remarkable attention in the last two decades because they can affect tumor growth and metastasis. There is a large body of evidence from in vivo and in vitro models showing that cannabinoids and their receptors influence the immune system, viral pathogenesis, and viral replication. The present study reviews current insights into the role of cannabinoids and their receptors on viral infections. The results reported here indicate that cannabinoids and their receptors have different sequels for viral infection. Although activation or inhibition of cannabinoid receptors in the majority of viral infections are proper targets for development of safe and effective treatments, caution is required before using pharmaceutical cannabinoids as a treatment agent for patients with viral infections.

KEYWORDS:

anti-inflammation; cannabinoid receptors; immunomodulation; marijuana; viral infections

PMID:
26059175
DOI:
10.1002/jmv.24292
[Indexed for MEDLINE]

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