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Br J Cancer. 2015 Jul 14;113(2):321-6. doi: 10.1038/bjc.2015.207. Epub 2015 Jun 9.

Expression of p16 in squamous cell carcinoma of the mobile tongue is independent of HPV infection despite presence of the HPV-receptor syndecan-1.

Author information

1
1] Department of Medical Biosciences, Umeå University, Umeå SE-901 85, Sweden [2] Multidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
2
Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
3
Department of Medical Biosciences, Umeå University, Umeå SE-901 85, Sweden.
4
Multidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
5
Department of Clinical Sciences, ENT, Uppsala University, Uppsala SE-751 05, Sweden.
6
Dipartimento Universitario di Anatomia Patologica, Seconda Universita' Degli Studi di Napoli, Piazza Miraglia, Naples 80138, Italy.
7
Department of Clinical and Experimental Medicine, University of Foggia, Foggia 71122, Italy.
8
Department of Clinical Sciences, Division of Otorhinolaryngology, Umeå University, Umeå SE-901 85, Sweden.
9
Department of Odontology, Umeå University, Umeå SE-90185, Sweden.
10
1] RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno 656 53, Czech Republic [2] University Paris Diderot, INSERM UMRS1162, 27 rue Juliette Dodu, Paris 75010, France.

Abstract

BACKGROUND:

Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased.

METHODS:

Samples from 109 patients with primary TSCC were analysed for the presence of HPV16 by in situ hybridisation and for expression of its surrogate marker p16 and the HPV receptor syndecan-1 by immunhistochemistry.

RESULTS:

No evidence of HPV16 DNA was observed in the tumours, although one-third showed p16 staining. There was no difference in the expression of the primary HPV receptor, syndecan-1, between TSCC and a group of tonsil SCC.

CONCLUSION:

Whereas p16 is expressed in some TSCCs, HPV16 is undetectable, therefore, p16 cannot be used as a surrogate marker for high-risk HPV-infection in this tumour. Despite presence of the HPV-receptor syndecan-1 in TSCC, HPV prefers the tonsillar environment. Lack of p16 associates with worse prognosis primarily in patients aged ⩽40 years with tongue SCC. The improved prognosis seen in p16-positive TSCC can be due to induction of a senescent phenotype or an inherent radiosensitivity due to the ability of p16 to inhibit homologous recombination repair.

PMID:
26057450
PMCID:
PMC4506391
DOI:
10.1038/bjc.2015.207
[Indexed for MEDLINE]
Free PMC Article

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