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JAMA. 2015 Jun 9;313(22):2276-7. doi: 10.1001/jama.2015.1881.

Nonsteroidal anti-inflammatory drugs for treatment of acute gout.

Author information

1
Department of Internal Medicine, Maastricht University Medical Center, the Netherlands2Centre Hospitalier Chrétien, Liège, Belgium.
2
Rheumatology Research Unit, Repatriation General Hospital, Daw Park, Australia4Flinders University, Bedford Park, Australia.
3
Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, the Netherlands6Department of Rheumatology, Atrium Medical Centre, Heerlen, the Netherlands.

Abstract

CLINICAL QUESTION:

Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with better outcomes than cyclooxygenase inhibitors, glucocorticoids, IL-1 inhibitors or placebo in the treatment of acute gout?

BOTTOM LINE:

NSAIDs are not significantly associated with a difference in pain reduction compared with cyclooxygenase inhibitors and glucocorticoids for treating acute gout. However, NSAIDs are associated with higher rates of adverse events and higher rates of withdrawal due to adverse events compared with cyclooxygenase inhibitors.

Comment on

PMID:
26057289
DOI:
10.1001/jama.2015.1881
[Indexed for MEDLINE]

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