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Curr Opin Chem Biol. 2015 Oct;28:9-14. doi: 10.1016/j.cbpa.2015.05.020. Epub 2015 Jun 5.

DNA nanotechnology: new adventures for an old warhorse.

Author information

1
Department of Electrical Engineering and Computer Science, Department of Biological Engineering, Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; MIT Synthetic Biology Center, 500 Technology Square, Cambridge, MA 02139, USA. Electronic address: bijan.zakeri@oxfordalumni.org.
2
Department of Electrical Engineering and Computer Science, Department of Biological Engineering, Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; MIT Synthetic Biology Center, 500 Technology Square, Cambridge, MA 02139, USA. Electronic address: timlu@mit.edu.

Abstract

As the blueprint of life, the natural exploits of DNA are admirable. However, DNA should not only be viewed within a biological context. It is an elegantly simple yet functionally complex chemical polymer with properties that make it an ideal platform for engineering new nanotechnologies. Rapidly advancing synthesis and sequencing technologies are enabling novel unnatural applications for DNA beyond the realm of genetics. Here we explore the chemical biology of DNA nanotechnology for emerging applications in communication and digital data storage. Early studies of DNA as an alternative to magnetic and optical storage mediums have not only been promising, but have demonstrated the potential of DNA to revolutionize the way we interact with digital data in the future.

PMID:
26056949
PMCID:
PMC4818966
DOI:
10.1016/j.cbpa.2015.05.020
[Indexed for MEDLINE]
Free PMC Article

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