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Curr Opin Immunol. 2015 Aug;35:39-47. doi: 10.1016/j.coi.2015.05.007. Epub 2015 Jun 8.

New approaches to HIV vaccine development.

Author information

1
Duke Human Vaccine Institute, Departments of Medicine and Immunology, Duke University School of Medicine, Durham, NC 27710, United States. Electronic address: barton.haynes@duke.edu.

Abstract

Development of a safe and effective vaccine for HIV is a major global priority. However, to date, efforts to design an HIV vaccine with methods used for development of other successful viral vaccines have not succeeded due to HIV diversity, HIV integration into the host genome, and ability of HIV to consistently evade anti-viral immune responses. Recent success in isolation of potent broadly neutralizing antibodies (bnAbs), in discovery of mechanisms of bnAb induction, and in discovery of atypical mechanisms of CD8T cell killing of HIV-infected cells, have opened new avenues for strategies for HIV vaccine design.

PMID:
26056742
PMCID:
PMC4553082
DOI:
10.1016/j.coi.2015.05.007
[Indexed for MEDLINE]
Free PMC Article

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