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Ultrasound Med Biol. 2015 Sep;41(9):2326-32. doi: 10.1016/j.ultrasmedbio.2015.05.001. Epub 2015 Jun 6.

Correlation between quantitative shear wave elastography and pathologic structures of thyroid lesions.

Author information

1
Department of Otolaryngology-Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan. Electronic address: tfukuhara3387@med.tottori-u.ac.jp.
2
Department of Otolaryngology-Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
3
Department of Pathology, Tottori University Faculty of Medicine, Yonago, Japan.
4
Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine, Yonago, Japan.

Abstract

The aim of this study was to determine the correlation between shear wave velocity (SWV) generated by acoustic radiation force impulse and the pathologic structure of thyroid lesions. A total of 599 thyroid tissue samples were divided into four groups based on pathologic structure: 254 normal thyroid tissue samples as a control, 128 with chronic autoimmune thyroiditis (CAT) that demonstrated diffuse fibrosis, 165 with benign nodules that had high cell density and 52 with papillary thyroid carcinoma (PTC) that showed high cell density and fibrosis. The mean SWVs in each group were as follows: 1.60 ± 0.18 m/s in normal thyroid, 2.55 ± 0.28 m/s in CAT, 1.72 ± 0.31 m/s in benign nodules and 2.66 ± 0.95 m/s in PTC. The SWVs of CAT and PTC were significantly higher than those of normal thyroid, (p < 0.001). SWV was significantly affected by fibrosis.

KEYWORDS:

Acoustic radiation force impulse; Chronic autoimmune thyroiditis; Fibrosis; Papillary thyroid carcinoma; Pathologic structure; Shear wave; Thyroid

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