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J Infect. 2015 Sep;71(3):302-11. doi: 10.1016/j.jinf.2015.05.012. Epub 2015 Jun 6.

Risk factors for resistance in urinary tract infections in women in general practice: A cross-sectional survey.

Author information

1
Département de Médecine Générale, UPMC Univ Paris 06, 27 rue Chaligny, 75012 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, 56, boulevard Vincent Auriol, CS 81393, 75646 Paris, France; INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, 56, boulevard Vincent Auriol, CS 81393, 75646 Paris, France. Electronic address: louise.rossignol@upmc.fr.
2
Institut de Veille Sanitaire, 12, rue du Val d'Osne, 94415 Saint-Maurice cedex, France. Electronic address: s.maugat@invs.sante.fr.
3
Institut de Veille Sanitaire, 12, rue du Val d'Osne, 94415 Saint-Maurice cedex, France. Electronic address: blake.alexandre@hotmail.fr.
4
Institut de Veille Sanitaire, 12, rue du Val d'Osne, 94415 Saint-Maurice cedex, France. Electronic address: s.vaux@invs.sante.fr.
5
Hopital universitaire Ambroise Paré AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France; Université Versailles-Saint-Quentin-en-Yvelines, 55 Avenue de Paris, 78000 Versailles, France. Electronic address: beate.heym@apr.aphp.fr.
6
Institut de Veille Sanitaire, 12, rue du Val d'Osne, 94415 Saint-Maurice cedex, France. Electronic address: y.lestrat@invs.sante.fr.
7
INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, 56, boulevard Vincent Auriol, CS 81393, 75646 Paris, France. Electronic address: solen.kerneis@cch.aphp.fr.
8
Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, 56, boulevard Vincent Auriol, CS 81393, 75646 Paris, France; INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, 56, boulevard Vincent Auriol, CS 81393, 75646 Paris, France. Electronic address: thierry.blanchon@upmc.fr.
9
Institut de Veille Sanitaire, 12, rue du Val d'Osne, 94415 Saint-Maurice cedex, France. Electronic address: b.coignard@invs.sante.fr.
10
INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, 56, boulevard Vincent Auriol, CS 81393, 75646 Paris, France; Hopital universitaire Ambroise Paré AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France; Université Versailles-Saint-Quentin-en-Yvelines, 55 Avenue de Paris, 78000 Versailles, France. Electronic address: thomas.hanslik@apr.aphp.fr.

Abstract

OBJECTIVES:

In 2012 and 2013, a cross-sectional survey was conducted in women visiting a general practitioner for a urinary tract infection (UTI) to i) describe the patterns of antibiotic resistance of Enterobacteriaceae involved in community-acquired UTIs and ii) identify the factors associated with UTIs due to a multi-drug-resistant Enterobacteriaceae (MDREB).

METHODS:

Urine analyses were performed systematically for all adult women presenting with signs of UTI. Characteristics of women with UTI due to MDREB were compared to those with UTI due to non-MDREB. Weighted logistic regressions were performed to adjust for the sampling design of the survey.

RESULTS:

Significant factors associated with MDREB included the use of penicillin by the patient in the last three months (OR = 3.1; [1.2-8.0]); having provided accommodation in the previous 12 months to a resident from a country at high risk for drug resistance (OR = 4.0; [1.2-15.1]); and the consumption of raw meat within the previous three months (OR = 0.3; [0.1-0.9]).

CONCLUSIONS:

In the community, antibiotic use and exposure to a person returning from an area with a high risk of drug resistance are associated with UTIs due to MDREB. The potentially protective role of raw meat consumption warrants further study.

KEYWORDS:

Antibiotic resistance; Epidemiology; General population; General practitioner; Risk factors; Urinary tract infection

PMID:
26054878
DOI:
10.1016/j.jinf.2015.05.012
[Indexed for MEDLINE]
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