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Nat Commun. 2015 Jun 9;6:7412. doi: 10.1038/ncomms8412.

Extreme multifunctional proteins identified from a human protein interaction network.

Author information

1
1] Aix-Marseille University, TAGC, Marseille F-13009, France [2] INSERM UMR_S1090, Marseille F-13009, France.
2
1] Aix-Marseille University, TAGC, Marseille F-13009, France [2] INSERM UMR_S1090, Marseille F-13009, France [3] Aix-Marseille University, CIML, Marseille F-13009, France [4] CNRS, UMR 7280, Marseille F-13009, France [5] INSERM, U631, Marseille F-13009, France.
3
1] Aix-Marseille University, TAGC, Marseille F-13009, France [2] INSERM UMR_S1090, Marseille F-13009, France [3] CNRS, Marseille F-13009, France.

Abstract

Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme multifunctional' proteins from an interactome as a first step to characterize moonlighting proteins. By combining network topological information with protein annotations, we identify 430 extreme multifunctional proteins (3% of the human interactome). We show that the candidates form a distinct sub-group of proteins, characterized by specific features, which form a signature of extreme multifunctionality. Overall, extreme multifunctional proteins are enriched in linear motifs and less intrinsically disordered than network hubs. We also provide MoonDB, a database containing information on all the candidates identified in the analysis and a set of manually curated human moonlighting proteins.

PMID:
26054620
PMCID:
PMC4468855
DOI:
10.1038/ncomms8412
[Indexed for MEDLINE]
Free PMC Article

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