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Br J Psychiatry. 1989 Jul;155:73-8.

Brain white-matter lesions and psychosis.

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  • 1Department of Neurology, Harbor-UCLA Medical Center, Torrance 90509.


In a prospective study of late-life onset psychosis, five of the first 27 patients studied had extensive white-matter lesions demonstrated by MRI and/or CT. None of 60 age-matched psychiatrically healthy controls demonstrated such lesions. All five patients had a mild dementia and a frontal behavioural syndrome. In addition, every patient performed poorly on neuropsychological tests of frontal function. Dysfunction of the frontal cortex associated with white-matter lesions appears to contribute to the clinical picture of some cases of late-life psychosis.

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