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Pediatr Blood Cancer. 2015 Oct;62(10):1694-9. doi: 10.1002/pbc.25592. Epub 2015 Jun 5.

Renal medullary carcinoma and sickle cell trait: A systematic review.

Author information

1
Division of Pediatric Hematology-Oncology, University of Miami, Miami, Florida.
2
Division of Pediatric Pathology, University of Miami, Miami, Florida.
3
Department of Public Health Sciences, University of Miami, Miami, Florida.
4
Division of Pediatric Hematology-Oncology, Children's Hospital of Michigan, Detroit, Michigan.

Abstract

Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N = 217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor-related mortality was 95%. Four non-metastatic patients were long-term disease-free survivors. Although risk appears to be very low, individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation.

KEYWORDS:

cancer; rare tumors; renal; sickle cell disease; sickle cell trait; tumors

PMID:
26053587
DOI:
10.1002/pbc.25592
[Indexed for MEDLINE]

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