Send to

Choose Destination
Trends Cogn Sci. 2015 Jul;19(7):394-405. doi: 10.1016/j.tics.2015.05.004. Epub 2015 Jun 4.

'Activity-silent' working memory in prefrontal cortex: a dynamic coding framework.

Author information

Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK. Electronic address:


Working memory (WM) provides the functional backbone to high-level cognition. Maintenance in WM is often assumed to depend on the stationary persistence of neural activity patterns that represent memory content. However, accumulating evidence suggests that persistent delay activity does not always accompany WM maintenance but instead seems to wax and wane as a function of the current task relevance of memoranda. Furthermore, new methods for measuring and analysing population-level patterns show that activity states are highly dynamic. At first glance, these dynamics seem at odds with the very nature of WM. How can we keep a stable thought in mind while brain activity is constantly changing? This review considers how neural dynamics might be functionally important for WM maintenance.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center