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Trends Genet. 2015 Aug;31(8):445-53. doi: 10.1016/j.tig.2015.05.002. Epub 2015 Jun 5.

Metabolic regulation in model ascomycetes--adjusting similar genomes to different lifestyles.

Author information

1
Biology Department, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada. Electronic address: malcolm.whiteway@concordia.ca.
2
Biology Department, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada.

Abstract

The related yeasts Saccharomyces cerevisiae and Candida albicans have similar genomes but very different lifestyles. These fungi have modified transcriptional and post-translational regulatory processes to adapt their similar genomes to the distinct biological requirements of the two yeasts. We review recent findings comparing the differences between these species, highlighting how they have achieved specialized metabolic capacities tailored to their lifestyles despite sharing similar genomes. Studying this transcriptional and post-transcriptional rewiring may improve our ability to interpret phenotype from genotype.

KEYWORDS:

Candida albicans; Saccharomyces cerevisiae; fungal metabolism; transcriptional regulators; transcriptional rewiring

PMID:
26051071
DOI:
10.1016/j.tig.2015.05.002
[Indexed for MEDLINE]

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