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Int J Surg. 2015 Aug;20:21-5. doi: 10.1016/j.ijsu.2015.05.047. Epub 2015 Jun 4.

FibroScan predicts ascites after liver resection for hepatitis B virus-related hepatocellular carcinoma: A prospective cohort study.

Author information

1
Division of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
2
Division of Ultrasonography, West China Hospital of Sichuan University, Chengdu 610041, China.
3
Division of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: ccwentianfu@sohu.com.

Abstract

OBJECTIVE:

To assess the correlation of preoperative FibroScan value and postoperative ascites in patients undergoing liver resection for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC).

METHODS:

A prospective study group of consecutive HBV-related HCC patients considered eligible for liver resection was conducted from 2012 to 2014 (N = 77). Liver stiffness measured by FibroScan was administrated to all patients. Patient's pre- and intra-operative variables were prospectively collected.

RESULTS:

FibroScan was successfully performed in 75 patients. Postoperative ascites was observed in 13 patients. Univariate analyses suggested tumor size, high preoperative hepatitis B viral load, intraoperative blood loss, major hepatectomy and FibroScan value were potential risk factors for postoperative ascites. However, in multivariate analysis, only FibroScan value (OR = 1.506, 95%CI = 1.21-1.87) showed prognostic power. The best cut-off value of FibroScan value to predict postoperative ascites was 15.6 kpa with a sensitivity of 76.9% and a specificity of 98.4%. The corresponding area under the receiver operating curve was 0.902.

CONCLUSIONS:

FibroScan value was a reliable surrogate marker for predicting postoperative ascites should be routinely performed in patients with HBV-related HCC undergoing liver resection.

KEYWORDS:

Ascites; FibroScan; Hepatocellular carcinoma; Liver resection

PMID:
26050952
DOI:
10.1016/j.ijsu.2015.05.047
[Indexed for MEDLINE]
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