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Neuron. 2015 Jun 3;86(5):1265-76. doi: 10.1016/j.neuron.2015.05.012.

Novelty-Induced Phase-Locked Firing to Slow Gamma Oscillations in the Hippocampus: Requirement of Synaptic Plasticity.

Author information

1
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Olav Kyrres gate 9, 7030 Trondheim, Norway. Electronic address: tkitanishi@outlook.com.
2
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
3
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Olav Kyrres gate 9, 7030 Trondheim, Norway; Warwick-NTU Neuroscience Programme, School of Biological Sciences, Nanyang Technological University, 61 Biopolis Drive, 138673, Singapore; Warwick-NTU Neuroscience Programme, School of Life Sciences, University of Warwick, Coventry, Gibbet Hill Road, Coventry, CV4 7AL, UK.
4
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Olav Kyrres gate 9, 7030 Trondheim, Norway.
5
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Center for Information and Neural Networks, 1-4 Yamadaoka, Suita City, Osaka, 565-0871, Osaka, Japan.
6
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Olav Kyrres gate 9, 7030 Trondheim, Norway; Warwick-NTU Neuroscience Programme, School of Biological Sciences, Nanyang Technological University, 61 Biopolis Drive, 138673, Singapore; Warwick-NTU Neuroscience Programme, School of Life Sciences, University of Warwick, Coventry, Gibbet Hill Road, Coventry, CV4 7AL, UK. Electronic address: atashiro@ntu.edu.sg.

Abstract

Temporally precise neuronal firing phase-locked to gamma oscillations is thought to mediate the dynamic interaction of neuronal populations, which is essential for information processing underlying higher-order functions such as learning and memory. However, the cellular mechanisms determining phase locking remain unclear. By devising a virus-mediated approach to perform multi-tetrode recording from genetically manipulated neurons, we demonstrated that synaptic plasticity dependent on the GluR1 subunit of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor mediates two dynamic changes in neuronal firing in the hippocampal CA1 area during novel experiences: the establishment of phase-locked firing to slow gamma oscillations and the rapid formation of the spatial firing pattern of place cells. The results suggest a series of events potentially underlying the acquisition of new spatial information: slow gamma oscillations, originating from the CA3 area, induce the two GluR1-dependent changes of CA1 neuronal firing, which in turn determine information flow in the hippocampal-entorhinal system.

PMID:
26050043
DOI:
10.1016/j.neuron.2015.05.012
[Indexed for MEDLINE]
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