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Soc Cogn Affect Neurosci. 2015 Dec;10(12):1758-68. doi: 10.1093/scan/nsv066. Epub 2015 Jun 5.

Mindfulness meditation training alters stress-related amygdala resting state functional connectivity: a randomized controlled trial.

Author information

1
Center for Neuroscience, University of Pittsburgh, Department of Psychology and Center for the Neural Basis of Cognition, Carnegie Mellon University.
2
Department of Psychology and Center for the Neural Basis of Cognition, University of Pittsburgh, and.
3
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
4
Department of Psychology and Center for the Neural Basis of Cognition, Carnegie Mellon University.
5
Department of Psychology, Virginia Commonwealth University, Richmond, MA, USA.
6
California State University, Los Angeles, CA 90032, USA, and.
7
Department of Psychology, University of Illinois, Chicago, IL, USA.
8
Department of Psychology and Center for the Neural Basis of Cognition, Carnegie Mellon University, creswell@cmu.edu.

Abstract

Recent studies indicate that mindfulness meditation training interventions reduce stress and improve stress-related health outcomes, but the neural pathways for these effects are unknown. The present research evaluates whether mindfulness meditation training alters resting state functional connectivity (rsFC) of the amygdala, a region known to coordinate stress processing and physiological stress responses. We show in an initial discovery study that higher perceived stress over the past month is associated with greater bilateral amygdala-subgenual anterior cingulate cortex (sgACC) rsFC in a sample of community adults (n = 130). A follow-up, single-blind randomized controlled trial shows that a 3-day intensive mindfulness meditation training intervention (relative to a well-matched 3-day relaxation training intervention without a mindfulness component) reduced right amygdala-sgACC rsFC in a sample of stressed unemployed community adults (n = 35). Although stress may increase amygdala-sgACC rsFC, brief training in mindfulness meditation could reverse these effects. This work provides an initial indication that mindfulness meditation training promotes functional neuroplastic changes, suggesting an amygdala-sgACC pathway for stress reduction effects.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01628809.

KEYWORDS:

amygdala; cingulate; health; mindfulness; stress

PMID:
26048176
PMCID:
PMC4666115
DOI:
10.1093/scan/nsv066
[Indexed for MEDLINE]
Free PMC Article

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