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J Autism Dev Disord. 2015 Oct;45(10):3255-61. doi: 10.1007/s10803-015-2486-6.

Low but increasing prevalence of autism spectrum disorders in a French area from register-based data.

Author information

1
Register for Severely Disabled Children and Perinatal Observatory (RHEOP), 23 Avenue Albert 1er de Belgique, 38000, Grenoble, France. maritvanbakel_rheop@orange.fr.
2
INSERM U.1027, 330 Avenue de Grand Bretagne, 31000, Toulouse, France.
3
Paul-Sabatier University, 31400, Toulouse, France.
4
Themas Team, UMR 5525, Joseph Fourier University, Domaine de la Merci, 38706, Grenoble, France.
5
Autism Resource Centre of the Rhone-Alpes Region, 3 rue de la Gare, 38521, St-Egreve, France.
6
Department of Genetics and Procreation, University Hospital Grenoble, Avenue du Maquis du Grésivaudan, 38700, Grenoble, France.
7
DYCTIM Team, UMR 5525 TIMC-IMAG, Joseph Fourier University Hospital, Domaine de la Merci, 38706, Grenoble, France.
8
Department of Child Psychiatry, La Grave University Hospital, Place Lange, 31059, Toulouse, France.
9
Department of Clinical Epidemiology, Purpan University Hospital, 31300, Toulouse, France.

Abstract

Register-based prevalence rates of childhood autism (CA), Asperger's syndrome (AS) and other autism spectrum disorders (ASD) were calculated among children aged 7 years old of the 1997-2003 birth cohorts, living in four counties in France. The proportion of children presenting comorbidities was reported. 1123 children with ASD were recorded (M/F ratio: 4.1), representing an overall prevalence rate of 36.5/10,000 children (95 % CI 34.4-38.7): 8.8/10,000 for CA (95 % CI 7.8-9.9), 1.7/10,000 for AS (95 % CI 1.3-2.3) and 25.9/10,000 for other ASD (95 % CI 24.2-27.8). ASD prevalence significantly increased (p < 0.0001) during the period under study. The proportion of children with an intellectual disability was 47.3 %, all other comorbidities were present in less than 5 % of the cases.

KEYWORDS:

Autism spectrum disorder; Comorbidities; Population register; Prevalence

PMID:
26048041
DOI:
10.1007/s10803-015-2486-6
[Indexed for MEDLINE]

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