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Diabetes Res Clin Pract. 2015 Aug;109(2):355-63. doi: 10.1016/j.diabres.2015.05.033. Epub 2015 May 18.

Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES).

Author information

1
Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy; Diabetes Unit, Sant'Andrea Hospital, Rome, Italy; Metabolic Fitness Association, Monterotondo, Rome, Italy.
2
Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy; Laboratory of Clinical Chemistry, Sant'Andrea Hospital, Rome, Italy.
3
Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy; Radiology Unit, Sant'Andrea Hospital, Rome, Italy.
4
Metabolic Fitness Association, Monterotondo, Rome, Italy; Department of Human Movement and Sport Sciences, "Foro Italico" University, Rome, Italy.
5
Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy; Metabolic Fitness Association, Monterotondo, Rome, Italy.
6
Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy.
7
Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy; Diabetes Unit, Sant'Andrea Hospital, Rome, Italy.
8
Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy.
9
Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy. Electronic address: giuseppe.pugliese@uniroma1.it.

Abstract

AIMS:

This study evaluated the effect of supervised exercise training on liver enzymes and two surrogate measures of non-alcoholic fatty liver disease (NAFLD) in subjects with type 2 diabetes.

METHODS:

Sedentary patients from 22 outpatient diabetes clinics were randomized by center, age and treatment to twice-a-week supervised aerobic and resistance training plus structured exercise counseling (exercise group, EXE; n=303) versus counseling alone (control group, CON; n=303) for 12 months. EXE participants were further randomized to low-to-moderate (n=142) or moderate-to-high (n=161) intensity training of equal energy cost. Baseline and end-of-study levels of liver enzymes, fatty liver index (FLI) and visceral adiposity index (VAI) were obtained.

RESULTS:

Enzyme levels did not change, whereas FLI and VAI decreased significantly in EXE, but not CON participants. Physical activity (PA) volume was an independent predictor of both FLI and VAI reductions, the extent of which increased from the 1st to the 4th quintile of PA volume and baseline to end-of-study changes in fitness parameters. Differences in the effect of LI versus HI training were negligible.

CONCLUSIONS:

Data from this large cohort of subjects with type 2 diabetes indicate that FLI and VAI decrease with supervised training in a volume-dependent manner.

KEYWORDS:

Exercise volume; FLI; Liver enzymes; Supervised exercise; VAI

PMID:
26047682
DOI:
10.1016/j.diabres.2015.05.033
[Indexed for MEDLINE]

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