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Cell Stem Cell. 2015 Jun 4;16(6):591-600. doi: 10.1016/j.stem.2015.05.004.

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency.

Author information

1
Developmental Biology and Center of Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10003, USA. Electronic address: studerl@mskcc.org.
2
Developmental Biology and Center of Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10003, USA.

Abstract

The ability to reprogram adult somatic cells back to pluripotency presents a powerful tool for studying cell-fate identity and modeling human disease. However, the reversal of cellular age during reprogramming results in an embryonic-like state of induced pluripotent stem cells (iPSCs) and their derivatives, which presents specific challenges for modeling late onset disease. This age reset requires novel methods to mimic age-related changes but also offers opportunities for studying cellular rejuvenation in real time. Here, we discuss how iPSC research may transform studies of aging and enable the precise programming of cellular age in parallel to cell-fate specification.

PMID:
26046759
PMCID:
PMC4508309
DOI:
10.1016/j.stem.2015.05.004
[Indexed for MEDLINE]
Free PMC Article

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