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Cell Stem Cell. 2015 Jun 4;16(6):572-3. doi: 10.1016/j.stem.2015.04.019.

Tex10: A New Player in the Core Pluripotency Circuitry.

Author information

1
Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel. Electronic address: yossibug@ekmd.huji.ac.il.

Abstract

Revealing how the core pluripotency circuitry is orchestrated to maintain the ground state of embryonic stem cells (ESCs) is fundamental for understanding self-renewal and early lineage specifications. In this issue of Cell Stem Cell, Ding et al. (2015) identify a new Sox2-interacting protein, Tex10, which, together with Tet1 and p300, regulate super-enhancers to sustain pluripotency.

PMID:
26046753
DOI:
10.1016/j.stem.2015.04.019
[Indexed for MEDLINE]
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