SnapShot: Spliceosome Dynamics I

Markus C Wahl; Reinhard Lührmann

doi:10.1016/j.cell.2015.05.050

SnapShot: Spliceosome Dynamics I

Cell. 2015 Jun 4;161(6):1474-e1. doi: 10.1016/j.cell.2015.05.050.

Authors

Markus C Wahl¹, Reinhard Lührmann²

Affiliations

¹ Laboratory of Structural Biochemistry, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.
² Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

PMID: 26046445
DOI: 10.1016/j.cell.2015.05.050

Abstract

Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, that is, the removal of non-coding intervening sequences (introns) from eukaryotic pre-mRNAs and the ligation of neighboring coding regions (exons) to produce mature mRNA for protein biosynthesis on the ribosome. They are the prototypes of dynamic molecular machines, assembling de novo for each splicing event by the stepwise recruitment of subunits on a substrate.

MeSH terms

Animals
Disease / genetics*
Humans
RNA Splicing*
Spliceosomes / metabolism*
Yeasts / genetics
Yeasts / metabolism*