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Mil Med Res. 2015 May 19;2:12. doi: 10.1186/s40779-015-0039-0. eCollection 2015.

Programmed cell death and its role in inflammation.

Author information

1
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 USA ; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433 China.
2
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433 China.
3
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 USA ; Research and Development, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240 USA.

Abstract

Cell death plays an important role in the regulation of inflammation and may be the result of inflammation. The maintenance of tissue homeostasis necessitates both the recognition and removal of invading microbial pathogens as well as the clearance of dying cells. In the past few decades, emerging knowledge on cell death and inflammation has enriched our molecular understanding of the signaling pathways that mediate various programs of cell death and multiple types of inflammatory responses. This review provides an overview of the major types of cell death related to inflammation. Modification of cell death pathways is likely to be a logical therapeutic target for inflammatory diseases.

KEYWORDS:

Apoptosis; Autophagy; Inflammation; NETosis; Necroptosis; Pyronecrosis; Pyroptosis

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