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AIDS Res Ther. 2015 May 21;12:18. doi: 10.1186/s12981-015-0054-y. eCollection 2015.

Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient.

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Department of Clinical Toxicology, University Hospital Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, Munich, 81675 Germany.
Department of Medicine II, Division of Infectious Diseases, University Of Wuerzburg Medical Center, Oberduerrbacherstr. 6, Wuerzburg, 97080 Germany.
Department of Medicine II and Interdisciplinary HIV Center (IZAR), University Hospital Klinikum Rechts Der Isar, Technische Universität München, Ismaningerstr. 22, Munich, 81675 Germany.


A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to levels measured prior to the intoxication. No other adverse events occurred, and the patient does not suffer from permanent impairments.


AIDS; Dolutegravir; Emtricitabine; HIV; Overdose; Suicide attempt; Tenofovir disaproxil fumarate

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