Format

Send to

Choose Destination
PLoS One. 2015 Jun 4;10(6):e0128780. doi: 10.1371/journal.pone.0128780. eCollection 2015.

Retinal Vessel Oxygen Saturation during 100% Oxygen Breathing in Healthy Individuals.

Author information

1
Department of Ophthalmology, University of Iceland, Reykjavik, Iceland; Department of Ophthalmology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.

Abstract

PURPOSE:

To detect how systemic hyperoxia affects oxygen saturation in retinal arterioles and venules in healthy individuals.

METHODS:

Retinal vessel oxygen saturation was measured in 30 healthy individuals with a spectrophotometric retinal oximeter (Oxymap T1). Oximetry was performed during breathing of room air, 100% oxygen (10 minutes, 6L/min) and then again room air (10 minutes recovery).

RESULTS:

Mean oxygen saturation rises modestly in retinal arterioles during 100% oxygen breathing (94.5%±3.8 vs. 92.0%±3.7% at baseline, p<0.0001) and dramatically in retinal venules (76.2%±8.0% vs. 51.3%±5.6%, p<0.0001). The arteriovenous difference decreased during 100% oxygen breathing (18.3%±9.0% vs. 40.7%±5.7%, p<0.0001). The mean diameter of arterioles decreased during 100% oxygen breathing compared to baseline (9.7±1.4 pixels vs. 10.3±1.3 pixels, p<0.0001) and the same applies to the mean venular diameter (11.4±1.2 pixels vs. 13.3±1.5 pixels, p<0.0001).

CONCLUSIONS:

Breathing 100% oxygen increases oxygen saturation in retinal arterioles and more so in venules and constricts them compared to baseline levels. The dramatic increase in oxygen saturation in venules reflects oxygen flow from the choroid and the unusual vascular anatomy and oxygen physiology of the eye.

PMID:
26042732
PMCID:
PMC4456093
DOI:
10.1371/journal.pone.0128780
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center