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Front Cell Neurosci. 2015 May 20;9:193. doi: 10.3389/fncel.2015.00193. eCollection 2015.

An updated role of microRNA-124 in central nervous system disorders: a review.

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1
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai China.

Abstract

MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.

KEYWORDS:

CNS disorders; CNS stress; brain development; brain tumor; microRNA-124; neurodegradation; neuroimmunity; stroke

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