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Alcohol Alcohol. 2015 Nov;50(6):690-9. doi: 10.1093/alcalc/agv057. Epub 2015 Jun 3.

Serotonin and Dopamine Candidate Gene Variants and Alcohol- and Non-Alcohol-Related Aggression.

Author information

1
Department of Psychiatry, Psychotherapy and Psychosomatics, Prignitz County Hospital, Martin-Luther University, Halle-Wittenberg, Germany ulrich.preuss@medizin.uni-halle.de.
2
Department of Psychiatry, Ludwig Maximilian University, München, Germany.
3
Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Szczecin, Poland.
4
Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
5
Department of Psychiatry, Psychotherapy and Psychosomatics, Prignitz County Hospital, Martin-Luther University, Halle-Wittenberg, Germany.
6
Department of Psychiatry, Ludwig Maximilian University, München, Germany Privatklinik Meiringen, Meiringen, Switzerland.

Abstract

AIMS:

Aggressive and criminal traits have a complex genetic background which interacts with environmental factors. Alcohol intoxication has been related to lower thresholds of aggressive behaviors. In this association study of two independent samples, a number of candidate gene variants (5HT2A T102C, 5-HTTLPR, DRD Ins-141Del, DAT1 VNTR) were related to violent criminal behavior and alcohol-related aggressive traits.

METHOD:

Treatment-seeking alcohol-dependent individuals (293 patients and 499 controls from Germany, 180 patients and 402 controls from Poland) underwent a Semi-Structured Assessment for the Genetics of Alcoholism interview which gathered information on alcohol-related violence and criminal behaviors, beside alcohol dependence characteristics.

RESULTS:

Patients with a history of violent or non-violent crime were more often male, had an earlier onset of alcoholism, more withdrawal seizures and delirium tremens, and were more likely to have a history of suicide attempts. No significant association between candidate gene variants and criminal behavior was detected. 5HTTLPR variant was related to one characteristic of alcohol-related violence.

CONCLUSIONS:

With findings from genome-wide association studies linking aggression-related traits to second messenger systems, further studies are needed to determine the genetic underpinnings of non-alcohol and alcohol-related aggression.

PMID:
26041607
DOI:
10.1093/alcalc/agv057
[Indexed for MEDLINE]

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