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Exp Biol Med (Maywood). 2015 Dec;240(12):1557-63. doi: 10.1177/1535370215588925. Epub 2015 Jun 2.

Effects of total gastrectomy on plasma silicon and amino acid concentrations in men.

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Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-950 Lublin, Poland II Department of Radiology, Medical University of Lublin, 20-081 Lublin, Poland
II Department of Radiology, Medical University of Lublin, 20-081 Lublin, Poland.
Department of Medical Chemistry, Medical University in Lublin, 20-093 Lublin, Poland.
II Department of General and Gastroenterological Surgery and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, 20-081 Lublin, Poland.
Department of Prosthetic Dentistry, Medical University in Lublin, 20-081 Lublin, Poland.
Vertebrates Morphology Department, Department of Zoology, Institute of Biology, Siedlce University of Natural Sciences and Humanities, 08-110 Siedlce, Poland.
Human Anatomy Department, Medical University in Lublin, 20-090 Lublin, Poland.


The aim of the study was to determine one-year effects of total gastrectomy on plasma silicon and free amino acid concentrations in patients and evaluate changes of volumetric bone mineral density (vBMD) in lumbar spine. Eight patients were enrolled to the control (CTR) group. Six patients subjected to total gastrectomy (GX group) were included to the experimental group. vBMD in trabecular and cortical bone was measured in lumbar vertebrae at baseline (before surgery) and one year later using quantitative computed tomography. Plasma concentrations of silicon and free amino acids were determined at baseline and one year later using photometric method and ion-exchange chromatography. Body weights within CTR and GX groups were not different after one-year follow-up when compared to the baseline values (P > 0.05). An average annual decrease of vBMD in the trabecular bone in the gastrectomized patients reached 15.0% in lumbar spine and was significantly different in comparison to the percentage changes observed in CTR group (P = 0.02). One-year percentage change of vBMD in the cortical bone in L1 and L2 has shown significantly decreased values by 10.5 and 9.1% in the GX group when compared to the percentage change observed in the controls (P < 0.05). Plasma concentration of adipic acid was significantly higher by 101.6% one year after total gastrectomy procedure in the patients when compared to the baseline value (P = 0.01). Plasma concentration of silicon was significantly lowered by 26.7% one year after the total gastrectomy when compared to the baseline value (P = 0.009). Total gastrectomy in patients has induced severe osteoporotic changes in lumbar spine within one-year period. The observed osteoporotic changes were associated with decreased plasma concentration of silicon indicating importance of exocrine and endocrine functions of stomach for silicon homeostasis maintenance. Gastrectomy-induced bone loss was not related to decreased amino acid concentration in plasma obtained from overnight fasted patients.


Gastrectomy; amino acids; osteoporosis; quantitative computed tomography; silicon

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