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Neurocase. 2016;22(1):76-83. doi: 10.1080/13554794.2015.1046458. Epub 2015 Jun 4.

Amyloid in dementia associated with familial FTLD: not an innocent bystander.

Author information

1
a Memory and Aging Center, Department of Neurology , University of California , San Francisco , CA , USA.
2
d Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine , University of California , Los Angeles , CA , USA.
3
b Department of Radiology , University of California , San Francisco , CA , USA.
4
c School of Public Health , University of California Berkeley and Lawrence Berkeley National Laboratory , Berkeley , CA , USA.

Abstract

Patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case-control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer's disease-like pattern of neurodegeneration.

KEYWORDS:

Alzheimer’s disease; FDG-PET; MRI; amyloid; frontotemporal dementia

PMID:
26040468
PMCID:
PMC4662906
DOI:
10.1080/13554794.2015.1046458
[Indexed for MEDLINE]
Free PMC Article

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