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Emerg Microbes Infect. 2013 Sep;2(9):e60. doi: 10.1038/emi.2013.58. Epub 2013 Sep 18.

IL-17 cytokines in immunity and inflammation.

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Tsinghua University School of Medicine , Beijing 100084, China.
Tsinghua University School of Medicine , Beijing 100084, China ; MD Anderson Cancer Center , Houston, TX 77054, USA.


Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In this review, we summarize the recent findings in IL-17 biology and the progress towards understanding the regulatory mechanisms of IL-17 expression and signaling mechanisms. This knowledge will benefit the development of novel immune modulators that enhance immunity to various infections and reduce inflammatory damage in infected patients.


IL-17 family cytokines; T helper 17; infection; inflammatory diseases

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