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Cancer Discov. 2015 Jun;5(6):584-5. doi: 10.1158/2159-8290.CD-15-0480.

Through a Clear Cell, Darkly: HIF2α/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress.

Author information

1
Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom.
2
Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom. rsj33@cam.ac.uk.

Abstract

Qiu and colleagues describe how a structural component of lipid droplets is markedly induced in pseudohypoxic renal tumors, where it maintains endoplasmic reticulum (ER) homeostasis. This adaptation is indispensable in tumor cells-where growth demands and a fluctuating blood supply place unnatural stresses on ER function-and is therefore an attractive therapeutic target.

PMID:
26037916
DOI:
10.1158/2159-8290.CD-15-0480
[Indexed for MEDLINE]
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