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Physiol Behav. 2015 Dec 1;152(Pt B):431-7. doi: 10.1016/j.physbeh.2015.05.032. Epub 2015 May 31.

Multiple estrogen receptor subtypes influence ingestive behavior in female rodents.

Author information

1
Department of Psychology, University at Buffalo, Buffalo, NY 14260, United States.
2
Department of Psychology, University at Buffalo, Buffalo, NY 14260, United States. Electronic address: danielsd@buffalo.edu.

Abstract

Postmenopausal women are at an increased risk of obesity and cardiovascular-related diseases. This is attributable, at least in part, to loss of the ovarian hormone estradiol, which inhibits food and fluid intake in humans and laboratory animal models. Although the hypophagic and anti-dipsogenic effects of estradiol have been well documented for decades, the precise mechanisms underlying these effects are not fully understood. An obvious step toward addressing this open question is identifying which estrogen receptor subtypes are involved and what intracellular processes are involved. This question, however, is complicated not only by the variety of estrogen receptor subtypes that exist, but also because many subtypes have multiple locations of action (i.e. in the nucleus or in the plasma membrane). This review will highlight our current understanding of the roles that specific estrogen receptor subtypes play in mediating estradiol's anorexigenic and anti-dipsogenic effects along with highlighting the many open questions that remain. This review will also describe recent work being performed by our laboratory aimed at answering these open questions.

KEYWORDS:

Estradiol; Food intake; Saline intake; Water intake

PMID:
26037634
PMCID:
PMC4661102
DOI:
10.1016/j.physbeh.2015.05.032
[Indexed for MEDLINE]
Free PMC Article

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