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Curr Biol. 2015 Jun 1;25(11):R450-2. doi: 10.1016/j.cub.2015.04.050.

Actin-filament disassembly: it takes two to shrink them fast.

Author information

1
Institute for Biophysical Chemistry, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.
2
Institute for Biophysical Chemistry, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany. Electronic address: faix.jan@mh-hannover.de.

Abstract

Actin-filament disassembly is indispensable for replenishing the pool of polymerizable actin and allows continuous dynamic remodelling of the actin cytoskeleton. A new study now reveals that ADF/cofilin preferentially dismantles branched networks and provides new insights into the collaborative work of ADF/cofilin and Aip1 on filament disassembly at the molecular level.

PMID:
26035785
DOI:
10.1016/j.cub.2015.04.050
[Indexed for MEDLINE]
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