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Nanoscale Res Lett. 2015 May 13;10:217. doi: 10.1186/s11671-015-0920-5. eCollection 2015.

Fabrication of Fe3O4@mSiO2 Core-Shell Composite Nanoparticles for Drug Delivery Applications.

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Instituto de Física, Universidad Autónoma de Puebla, Apdo. Postal J-48, Puebla, 72570 Mexico.
Department of Chemistry, Korea Center for Artificial Photosynthesis, Sogang University, 35, Baekbeom-ro, Mapo-gu, Seoul 121-742 Republic of Korea.
Department of Life Science, Laboratory of Molecular and Cellular Biology, Sogang University, 35, Baekbeom-ro, Mapo-gu, Seoul 121-742 Republic of Korea.


We report the synthesis of Fe3O4@mSiO2 nanostructures of different meso-silica (mSiO2) shell thickness, their biocompatibility and behaviors for loading and release of a model drug ibuprofen. The composite nanostructures have superparamagnetic magnetite cores of 208 nm average size and meso-silica shells of 15 to 40 nm thickness. A modified Stöber method was used to grow the meso-silica shells over the hydrothermally grown monodispersed magnetite particles. The composite nanoparticles show very promising drug holding and releasing behaviors, which depend on the thickness of meso-silica shell. The biocompatibility of the meso-silica-coated and uncoated magnetite nanoparticles was tested through cytotoxicity assay on breast cancer (MCF-7), ovarian cancer (SKOV3), normal human lung fibroblasts MRC-5, and IMR-90 cells. The high drug holding capacity and reasonable biocompatibility of the nanostructures make them ideal agents for targeted drug delivery applications in human body.


Core-shell; Magnetite; Porous composite nanoparticle

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