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Tetrahedron Lett. 2015 Jun 3;56(23):3396-3401.

Synthesis of the diaryl ether cores common to chrysophaentins A, E and F.

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Department of Chemistry, University of California, One Shields Ave, Davis, CA 95616.


The synthesis of the diaryl ether subunits of the marine natural products chrysophaentin A, E and F is described. These natural prodcuts feature tetrasubstituted benzene rings with complex substitution patterns. The central strategy involves an SNAr reaction between a complex phenol and a polysubstituted fluoronitrobenzene. Subseqent attempts to construct the unusual E-chloroalkene linkage through several different approaches are also disclosed.


Chrysophaentin; Claisen; FtsZ; Natural Product Synthesis; SNAr

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