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Antimicrob Agents Chemother. 2015 Aug;59(8):5061-4. doi: 10.1128/AAC.00921-15. Epub 2015 Jun 1.

Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays.

Author information

1
Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California, USA roland.cooper@dominican.edu.
2
Department of Medicine, University of California, San Francisco, California, USA.
3
Department of Integrative Biology, University of California, Berkeley, California, USA.
4
Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California, USA.
5
Infectious Diseases Research Collaboration, Kampala, Uganda.

Abstract

We evaluated markers of artemisinin resistance in Plasmodium falciparum isolated in Kampala in 2014. By standard in vitro assays, all isolates were highly sensitive to dihydroartemisinin (DHA). By the ring-stage survival assay, after a 6-h DHA pulse, parasitemia was undetectable in 40 of 43 cultures at 72 h. Two of 53 isolates had nonsynonymous K13-propeller gene polymorphisms but did not have the mutations associated with resistance in Asia. Thus, we did not see evidence for artemisinin resistance in Uganda.

PMID:
26033725
PMCID:
PMC4505276
DOI:
10.1128/AAC.00921-15
[Indexed for MEDLINE]
Free PMC Article

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