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Bull Exp Biol Med. 2015 May;159(1):48-52. doi: 10.1007/s10517-015-2887-8. Epub 2015 Jun 2.

Effects of Phenibut and Citrocard on Non-Competitive and Competitive Behavior during Provoked Aggression in Animals.

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Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia,


Anti-aggressive effects of phenibut (25 mg/kg) and its structural analogue citrocard (50 mg/kg) were revealed in rats under condition of provoked intraspecific aggression. These substances significantly decreased manifestations of aggression in animals: they increased the latency of attacks and reduced their number. Anti-aggressive effects of citrocard were more pronounced than effects of phenibut under conditions of non-competitive aggression induced by fear of inescapable painful exposure or under conditions of competitive aggression reflecting the ability of animals to reveal adaptive social communicative skills in aversive situation.

[Indexed for MEDLINE]

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