Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats

E E Khirazova; A A Bayzhumanov; E S Motorykina; A A Devyatov; M V Maslova; A V Graf; N A Sokolova; M G Golubeva; A A Kamenskii

doi:10.1007/s10517-015-2884-y

Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats

Bull Exp Biol Med. 2015 May;159(1):38-40. doi: 10.1007/s10517-015-2884-y. Epub 2015 Jun 2.

Authors

E E Khirazova¹, A A Bayzhumanov, E S Motorykina, A A Devyatov, M V Maslova, A V Graf, N A Sokolova, M G Golubeva, A A Kamenskii

Affiliation

¹ Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia, ekhirazova@gmail.com.

PMID: 26033586
DOI: 10.1007/s10517-015-2884-y

Abstract

We studied the effects of anorectic peptide obestatin and its fragment (1-4) on the antioxidant defense system in animals with normal and experimentally induced increased body weight. In rats with normal body weight, no changes in activity of the antioxidant defense system 1 week after single administration of the substances. After chronic administration of obestatin and fragment (1-4) for 1 week, total antioxidant capacity of the plasma decreased; obestatin also lowered the content of TBA-reactive products. In the overweight rats, SOD-like activity in the plasma increased 1 week after chronic administration of obestatin. Hence, obestatin and its fragment (1-4) induced changes in the antioxidant defense system only after chronic administration.

Publication types

Comparative Study

MeSH terms

Amino Acid Sequence
Animals
Antioxidants / analysis*
Appetite Depressants / administration & dosage
Appetite Depressants / pharmacology*
Appetite Depressants / therapeutic use
Catalase / blood
Diet, High-Fat / adverse effects
Drug Administration Schedule
Drug Evaluation, Preclinical
Male
Molecular Sequence Data
Overweight / blood
Overweight / drug therapy*
Overweight / etiology
Peptide Fragments / administration & dosage
Peptide Fragments / pharmacology*
Peptide Hormones / administration & dosage
Peptide Hormones / pharmacology*
Peptide Hormones / therapeutic use
Rats
Rats, Wistar
Superoxide Dismutase / blood

Substances

Antioxidants
Appetite Depressants
Peptide Fragments
Peptide Hormones
obestatin, rat
Catalase
Superoxide Dismutase