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Adv Mater. 2015 Jul 15;27(27):4035-40. doi: 10.1002/adma.201501099. Epub 2015 Jun 1.

3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures.

Hong S1, Sycks D1, Chan HF2, Lin S1,3, Lopez GP1,2, Guilak F1,2,4, Leong KW2,5, Zhao X1,3,6.

Author information

1
Department of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.
2
Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
3
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
4
Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, 27710, USA.
5
Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
6
Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Abstract

A 3D printable and highly stretchable tough hydrogel is developed by combining poly(ethylene glycol) and sodium alginate, which synergize to form a hydrogel tougher than natural cartilage. Encapsulated cells maintain high viability over a 7 d culture period and are highly deformed together with the hydrogel. By adding biocompatible nanoclay, the tough hydrogel is 3D printed in various shapes without requiring support material.

KEYWORDS:

3D printing; cellularized structure; nanoclay; poly (ethylene glycol)-alginate; tough hydrogel

PMID:
26033288
PMCID:
PMC4849481
DOI:
10.1002/adma.201501099
[Indexed for MEDLINE]
Free PMC Article

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