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Neurosci Lett. 2015 Jul 23;600:22-7. doi: 10.1016/j.neulet.2015.05.055. Epub 2015 May 29.

Activation of hypothalamic oxytocin neurons following tactile stimuli in rats.

Author information

1
Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Shimotsuke-shi, Tochigi-ken 329-0498, Japan.
2
Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Shimotsuke-shi, Tochigi-ken 329-0498, Japan. Electronic address: tonaka@jichi.ac.jp.

Abstract

Gentle touching or stroking has anxiolytic actions and contributes to the establishment of an intimate relationship between individuals. Oxytocin administration also has anxiolytic actions and facilitates social behaviors. In this study, we examined effects of stroking stimuli on activation of oxytocin neurons and emission of 50-kHz ultrasonic vocalizations, an index of positive emotion, in rats. The number of oxytocin neurons expressing Fos protein was increased in the hypothalamus, especially in the dorsal zone of the medial parvicellular part of the paraventricular nucleus. The number of 50-kHz ultrasonic vocalizations was also increased. These findings suggest that pleasant sensory stimuli activate hypothalamic oxytocin neurons.

KEYWORDS:

Fos protein; Hypothalamus; Oxytocin; Stroking; Touch; Ultrasonic vocalizations

PMID:
26033183
DOI:
10.1016/j.neulet.2015.05.055
[Indexed for MEDLINE]

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