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J Autism Dev Disord. 2015 Oct;45(10):3232-42. doi: 10.1007/s10803-015-2483-9.

Defining treatment response and symptom remission for anxiety disorders in pediatric autism spectrum disorders using the Pediatric Anxiety Rating Scale.

Author information

1
Department of Pediatrics, University of South Florida, St. Petersburg, FL, USA. cjohnco@health.usf.edu.
2
Rothman Center for Pediatric Neuropsychiatry, Child Development and Rehabilitation Center, 880 6th Street South Suite 460, Box 7523, St. Petersburg, FL, 33701, USA. cjohnco@health.usf.edu.
3
Department of Psychology, University of South Florida, Tampa, FL, USA.
4
Department of Pediatrics, University of South Florida, St. Petersburg, FL, USA.
5
Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA.
6
Department of Psychology, University of Miami, Miami, FL, USA.
7
Division of Child Psychiatry, University of California, Los Angeles, CA, USA.
8
Division of Psychological Studies in Education, University of California, Los Angeles, CA, USA.
9
Department of Health Policy and Management, University of South Florida, Tampa, FL, USA.
10
Rogers Behavioral Health - Tampa Bay, Tampa, FL, USA.
11
All Children's Hospital - Johns Hopkins Medicine, St. Petersburg, FL, USA.

Abstract

This study examined optimal guidelines to assess treatment response and remission for anxiety in youth with autism spectrum disorders (ASD) using the Pediatric Anxiety Rating Scale (PARS). Data was collected for 108 children aged 7-16 years with comorbid anxiety and ASD before and after receiving cognitive behavior therapy. Optimal cut-offs on the PARS were assessed using signal detection analyses using receiver operating characteristic methods. Maximum agreement with response criteria was achieved at 15 % reduction in symptoms on the PARS. Maximum agreement with remission criteria was achieved at 40 % reduction in symptoms, or at a score of 10 or below at post-treatment. Results have implications for standardizing criteria used in research trials and clinical practice.

KEYWORDS:

Autism; Children; Measurement; Pediatric Anxiety Rating Scale; Treatment

PMID:
26031924
PMCID:
PMC4574290
DOI:
10.1007/s10803-015-2483-9
[Indexed for MEDLINE]
Free PMC Article

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