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Tissue Antigens. 2015 Jul;86(1):32-5. doi: 10.1111/tan.12587. Epub 2015 Jun 2.

Low occurrence of the HLA-C*04:09N allele in a large Hungarian cohort.

Author information

1
Laboratory of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, Hungary.
2
Laboratory of Transplantation Immunogenetics, Hungarian National Blood Transfusion Service, Budapest, Hungary.
3
Bone Marrow Donor Registry, Hungarian National Blood Transfusion Service, Budapest, Hungary.

Abstract

The presence of null alleles may affect the outcome of stem cell transplantation. HLA-C*04:09N was defined as 'common' with a frequency of 2-5/1000 in Caucasians, and its presence is routinely tested as part of haplotypes HLA-A*02:01/A*23:01-B*44:03-DRB1*07:01-DQB1*02:01. We aimed to investigate HLA-C*04:09N in a representative Hungarian cohort. HLA-typing data of 7345 unrelated persons were analyzed. The presence of HLA-C*04:09N was excluded in 157 chromosomes with either serology typing or with an allele-specific polymerase chain reaction for HLA-C*04:09N. HLA-C*04:09N was identified in a single chromosome with HLA-A*02, B*44, C*04, DRB1*07 resulting in a HLA-C*04:09N allele frequency of 0.0068% (1/14,690). This is approximately a 10- to 40-fold lower frequency compared with the previous data. Our results emphasize the need of precise local population-specific HLA-data, allowing appropriate modifications of local HLA-typing protocols.

KEYWORDS:

HLA-C*04:09N; HLA-typing; Hungarian population; common haplotype; null-allele

PMID:
26031704
DOI:
10.1111/tan.12587
[Indexed for MEDLINE]

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