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Chemistry. 2015 Jul 6;21(28):10220-5. doi: 10.1002/chem.201406670. Epub 2015 Jun 1.

In Situ Formation of Dual-Phase Thermosensitive Ultrasmall Gold Nanoparticles.

Author information

1
School of Chemistry and Molecular Engineering, East China Normal University, 500 N, Dongchuan Road, Shanghai, 200241 (P. R. China).
2
School of Chemistry and Molecular Engineering, East China Normal University, 500 N, Dongchuan Road, Shanghai, 200241 (P. R. China). khuang@chem.ecnu.edu.cn.

Abstract

A novel method for the in situ synthesis of dual-phase thermosensitive ultrasmall gold nanoparticles (USGNPs) with diameters in the range of 1-3 nm was developed by using poly(N-isopropylacrylamide)-block-poly(N-phenylethylenediamine methacrylamide) (PNIPAM-b-PNPEDMA) amphiphilic diblock copolymers as ligands. The PNPEDMA block promotes the in situ reduction of gold precursors to zero-valent gold and subsequently binds to the surface of gold nanoparticles, while PNIPAM acts as a stabilizing and thermosensitive block. The as-synthesized USGNPs stabilized by a thermosensitive PNIPAM layer exhibit a sharp, reversible, clear-opaque transition in aqueous solution between 30 and 38 °C. An unprecedented finding is that these USGNPs also show a reversible soluble-precipitate transition in nonpolar organic solvents such as chloroform at around 0 °C under acidic conditions.

KEYWORDS:

block copolymers; gold; nanoparticles; thermoresponsive materials

PMID:
26031407
DOI:
10.1002/chem.201406670

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