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PLoS One. 2015 Jun 1;10(6):e0128232. doi: 10.1371/journal.pone.0128232. eCollection 2015.

Opioids contribute to fracture risk: a meta-analysis of 8 cohort studies.

Author information

1
Department of Orthopedic Surgery, The People's Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi, Yunan, China.
2
Department of Nephrology, The People's Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi, Yunan, China.
3
Department of Anesthesiology, The People's Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi, Yunan, China.
4
Trauma Center of Yunnan Province, The Second People's Hospital of Yunnan Province, Kunming, Yunan, China.

Abstract

OBJECTIVE:

To evaluate the association between chronic opioid use for non-cancer pain and fracture risk by conducting a meta-analysis of cohort studies.

METHODS:

Cohort studies were identified by searching PubMed and EMBASE from their inception to July 2014. A fracture was considered an endpoint. The information was extracted by two authors independently. When the heterogeneity was significant, a random-effects model was used to calculate the overall pooled risk estimates.

RESULTS:

Eight cohort studies were included in the final meta-analysis. On the basis of the Newcastle-Ottawa Scale (NOS), six studies were considered to be of high quality. The overall combined relative risk for the use of opioids and fractures was 1.88 (95% confidence interval [CI] 1.51-2.34). A subgroup analysis revealed the sources of heterogeneity. The sensitivity analysis indicated stable results, and no publication bias was observed.

CONCLUSIONS:

This meta-analysis of cohort studies demonstrates that opioids significantly increase the risk of fractures.

PMID:
26030421
PMCID:
PMC4452583
DOI:
10.1371/journal.pone.0128232
[Indexed for MEDLINE]
Free PMC Article

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